Tollo

This Drosophila melanogaster protein, encoded by gene CG6890, belongs to the family of proteins related to the Toll receptor and is being referred to also as Toll-8 (Tauszig et al, 2000).

Seppo et al (2003) have reported that in wild-type embryos, Tollo is expressed by ectodermal cells that surround differentiating neurons and precedes the appearance of an N-linked oligosaccharide epitope expressed on a subset of neuronal glycoproteins. Re-introduction of Tollo into null embryos rescues neural-specific glycan expression. Thus, loss of an ectodermal cell surface protein alters glycosylation in juxtaposed differentiating neurons. Aoki et al (2007) have reported complex changes in N-linked glycan complexity in tollo mutants.

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Entry last modified: January 2005