VAD

The synthetic tripeptide VAD (Val-Ala-Asp) coupled to fluoromethylketone (VAD-fmk), the N-benzyloxycarbonyl derivative (zVAD), or the N-benzyloxycarbonyl / fluoromethylketone derivative (zVAD-fmk) are synthetic permeable inhibitors of caspases (caspase-1) that have the same spectrum of activity as derivatives of YVAD (for overview see: Van Noorden, 2001). Another derivative (Ac-VAD-CMK; N-Acetyl-VAD-chloromethyl ketone derivative) is another inhibitor with a broad spectrum. Treatment of cells with this compound can inhibit characteristic biochemical and morphological events associated with cell death by apoptosis, which is usually taken as evidence for the inhibition of ... ... ... ...
 
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Entry last modified: January 2018