WKGKMVKLYVLGSVLALFGVVLGLMETVCSPFTA |
WKYMVM |
AvBD7 |
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This synthetic peptide (Trp-Lys-Tyr-Val-D-Met) (also referred to as W peptide) has been selected from random peptide libraries on the basis of its ability to stimulate phosphoinositide hydrolysis in lymphocytes (Baek et al, 1996; Seo et al, 1997). This peptide cannot be classified as one of the cytokines or growth factors due to its small molecular weight (see also: regulatory peptide factors). WKYMVm activates receptors FPR1, FPRL1, and FPRL2 in a calcium mobilization assay (Christophe et al, 2001). WKYMVm peptide stimulates phosphoinositide hydrolysis in several hematopoietic cell lines (U937
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