U937

(ATCC: CRL 1593) A human cell line established from a diffuse histiocytic lymphoma of a 37 year old male patient. This cell line is one of the few cell lines displaying many monocytic characteristics and has thus served as a model for the differentiation of monocytes and macrophages in vitro.

The cells are committed to the macrophage branch of the myeloid lineage and can be induced by a variety of agents to mature from a promonocytic into a monocytic stage of development. This process is accompanied by the acquisition of a number of morphological and functional attributes normally associated with mature macrophages ... ... ... ...
 
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Entry last modified: January 2002