WNSNRRFRVGRPPVVGRPGCVCFRAPCPCSNYamide |
Wnt-1 induced secreted protein-1 |
RNF114 |
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[Wnt family member 1; wingless-type MMTV integration site family member 1] This protein is one member of the so-called Wnt family of proteins (Nusse et al, 1991). It has been identified originally as a chromosomal site of insertion of mouse mammary tumor virus (MMTV) on mouse chromosome 15 (see: int-1).
Mice homozygous for a Wnt-1 null mutation exhibit a range of phenotypes from death before birth to survival with severe ataxia. Severe abnormalities in the development of the mesencephalon and metencephalon during embryogenesis suggest a prominent role for the Wnt-1 protein in the induction of the mesencephalon and cerebellum (McMahon and Bradley, 1990; Thomas and Capecchi, 1990). Male transgenic mice
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