Wnt-1

[Wnt family member 1; wingless-type MMTV integration site family member 1] This protein is one member of the so-called Wnt family of proteins (Nusse et al, 1991). It has been identified originally as a chromosomal site of insertion of mouse mammary tumor virus (MMTV) on mouse chromosome 15 (see: int-1).

Wnt-1 has been identified as a regulator of bone formation and remodelling. Mutations in the Wnt-1 gene cause early-onset osteoporosis and osteogenesis imperfecta, a heritable skeletal disorder characterized by bone fragility and low bone mass (Keupp et al, 2013; Won et al, 2017; Laine et al, 2013) Luther et al (2018) have reported a high prevalence of heterozygous Wnt-1 mutations in patients with early-onset osteoporosis. The inactivation of Wnt-1 in osteoblasts ... ... ... ...
 
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Entry last modified: September 2017