Wnt-9b |
Wnt-10b |
Caspase-8 and FADD-like apoptosis regulator |
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[Wnt family member 10a; wingless-type MMTV integration site family member 10a] Wnt-10a is one member of the so-called Wnt family of proteins (Nusse et al, 1991). The human Wnt-10a gene has been identified by Kirikoshi et al (2001). The mouse gene has been cloned by Wang and Shackleford (1996). Wnt-10a shares 59.2 % amino acid sequence identity with human Wnt-10b. The gene is expressed in fetal kidney, placenta, and adult spleen and at low levels in fetal lung, adult kidney, prostate, and ovary. Some human cancer cell lines overexpress the protein (Kirikoshi et al, 2001).
Narita et al (2005) have reported an involvement of chicken Wnt-10a in the formation of the apical
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