diffusible survival evasion peptide |
DIGF-2 |
OIAS |
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[dexamethasone-induced gene 2] dig2 is a gene the expression of which in the murine T-cell lymphoma lines S49.A2 and WEHI7.2, and in normal mouse thymocytes is induced significantly by dexamethasone (Wang et al, 2003). dig2 is a stress response gene. Its expression is induced in response to a variety of cellular stressors including thapsigargin, tunicamycin, and heat shock. Expression is upregulated also after treatment with the apoptosis inducing drug, etoposide. Overexpression of dig2 reduces the sensitivity of WEHI7.2 cells to dexamethasone-induced apoptosis.
dig2 has been shown to be identical with DDIT4 [
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