E-rosette receptor |
ERp46 |
tissue-specific stem cells |
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[externally regulated phosphatase] erp is a growth factor-inducible non-transmembrane tyrosine phosphatase of 367 amino acids (Noguchi et al, 1993). erp also displays serine protein phosphatase activity. The protein displays significant similarity to Vaccinia virus protein phosphatase VH1. It is known also as CL100, 3CH134 or mitogen-activated kinase phosphatase-1 (MKP-1).
In some cells the expression of erp is induced by IL3 and erythropoietin (Ofir et al, 1997). Overexpression of erp in NIH 3T3 cells leads to a pronounced decrease in proliferation rate. An analysis of erp expression during mouse
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