MPR300 |
MPRI |
Scotin |
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This gene has been identified in Staphylococcus aureus. Expression of mprF renders cells resistant to antimicrobial proteins such as defensins and protegrins (Peschel et al, 2001). mprF mutants strains are killed considerably faster by human neutrophils and exhibit attenuated virulence in mice. The analysis of membrane lipids reveals that mprF mutants no longer modify phosphatidylglycerol with L-lysine. As this unusual modification leads to a reduced negative charge of the membrane surface, peptide resistance mediated by mprF is most likely based on repulsion of the cationic peptides.
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