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also: patched-1. Abbr. PTCH1 ([patched homolog 1] approved gene symbol), PTCH, PTC, PTC1. The human gene (Johnson et al, 1996; Hahn et al, 1996), is the homolog of the Drosophila melanogaster patched gene (abbr. ptc; gene: CG2411), which encodes a transmembrane receptor for some members of the TGF-beta family and Wnt family of proteins and is involved in regulating segment polarity. For a second homolog see: patched-2.
The protein is a receptor for Sonic hedgehog and other hedgehog
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