progenipoietin

abbr. ProGP. Chimeric dual agonist chimeric hematopoietic growth factors (see also: Muteins). These engineered proteins are cytokine receptor agonists that combine activites binding to the human fetal liver tyrosine kinase flt-3 and the G-CSF receptor. They bind simultaneously to both receptors with affinities approximately two- to three-fold higher than the respective native ligands (Streeter et al, 2001).

Variants, which differ in the orientation of the two receptor agonists, are ProGP-1 [progenipoietin-1], ProGP-2 [progenipoietin-2], and ProGP-4 [progenipoietin-4 ... ... ... ...
 
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Entry last modified: March 2003