sFRP3

[secreted frizzled-related protein 3] This protein is a member of a family of secreted proteins that appear to act as soluble modulators of Wnt family signaling. They compete with membrane-bound receptors belonging to the frizzled family for the binding of secreted Wnt family ligands (Jones and Jomary, 2002).

The gene encoding this protein has been identified as a member of a family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand binding domain found in the frizzled family of transmembrane receptors (Rattner et al, 1997). sFRP3 is known also as frizzled-related protein 1 (Leyns et al, 1997), or FrzB1 ( ... ... ... ...
 
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Entry last modified: March 2003