tendon forming cells |
Tenecin-1 |
Alpha-1-acid glycoprotein 2 |
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abbr. TSPC. This cell type with universal stem cell characteristics such as clonogenicity, multipotency, and self-renewal capacity has been isolated from human and mouse tendons. The isolated cells have been shown to be able to regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo. These cells reside within a unique niche predominantly comprised of an extracellular matrix and biglycan and fibromodulin being two critical components that organize this niche. Depletion of these two proteins affects the differentiation of these stem cells by modulating
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