ADAM15 |
ADAM18 |
SDF-1-epsilon |
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[a disintegrin and metalloprotease domain 17; ADAM metallopeptidase domain 17] This protein is known also as TACE [TNF-alpha converting enzyme]; see: TACA [TNF-alpha converting activity]. It is a member of the ADAM protein family. In the nomenclature of CD antigens this protein has been given the designation CD156b.
ADAM17 has been shown to be involved in ectodomain shedding of membrane-anchored ACE2, the receptor for SARS-CoV-2, the virus causing coronavirus disease 2019 (COVID-19) (Xu et al, 2017). Biologically active, cell membrane-bound ADAM17 also plays a critical role in the release of biologically active cytokines, such as
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