Astakine
Astakine, called also Astakine 1 is an endogenous cytokine-like factor from the freshwater crayfish Pacifastacus leniusculus. For a related factor see: Astakine 2.
Astakine is required for the differentiation and growth of hemopoietic stem cells in vitro (Söderhäll et al, 2005). Astakine induces a strong hematopoiesis response in live animals. An astakine homolog has been found in the shrimp, Penaeus monodon, where it appears to be significantly expressed at all larval stages. Astakine is considered a homolog of vertebrate prokineticins (prokineticin-1, prokineticin-2). Astakine contains a conserved domain
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