BCL10

[B-cell lymphoma/leukemia-10] This gene is located near the breakpoint of a specific chromosomal translocation in a B-cell lymphoma of mucosa-associated lymphoid tissue (Willis et al, 1999). It is a cellular homologous sequence of the equine herpesvirus-2 gene E10 (see also: CLAP, CIPER). The protein has a length of 233 amino acids. Both proteins contain a CARD domain found also in several other proteins associated with apoptosis.

Xue et al (2003) have reported that BCL10 is essential for the development of all subsets of mature B-cells. They have generated healthy, fertile mice lacking expression of BCL10. These animals show a reduction in the number of ... ... ... ...
 
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Entry last modified: March 2014