CES-2

[Cell Death Specification-2] The Caenorhabditis elegans gene CES-2 encodes a transcription factor. The CES-2 protein is most similar to members of the PAR (proline- and acid-rich) subfamily of bZIP proteins and has DNA-binding specificity like that of PAR-family proteins (Metzstein et al, 1996). An oncogenic form of the mammalian PAR family protein, hepatic leukemia factor (HLF), has been reported to effect programmed cell death in mammalian cells.

CES-2, together with CES-1, controls the decisions of two sister cells of the serotoninergic neurosecretory motor (NSM) neurons in the nematode to undergo ... ... ... ...
 
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Entry last modified: June 2003