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abbr. CASP11. This enzyme is a member of a family of evolutionarily conserved cysteine protease proteins known as caspases. Many of these enzymes are part of a proteolytic cascade that plays a central role in cell death by apoptosis. Caspase-11 has been isolated and characterized as ICH-3 [ICE and CED3 homolog-3]. Mouse Caspase-11 is considered the murine homolog of human caspase-4 (Van de Craen et al, 1997).
Caspase-11 gene expression in response to bacterial lipopolysaccharides and IFN-gamma requires NF-kappa-B and the signal transducer STAT1
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