GSDF

[gonadal soma-derived growth factor] The gene encoding GSDF has been cloned by Sawatari et al (2007). It encodes a rainbow trout (Oncorhynchus mykiss) member of the TGF-beta superfamily. GSDF is expressed in the genital ridge somatic cells surrounding the primordial germ cells during embryogenesis, and in granulosa cells and Sertoli cells at later stages. Inhibition of GSDF suppressed the proliferation of primordial germ cells. Treatment of isolated testicular cells with recombinant GSDF causes the proliferation of type-A spermatogonia and the effect is blocked completely by an antiserum against GSDF.

GSDF has been identified also in a number of other teleost fish ... ... ... ...
 
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Entry last modified: September 2014