H-IL6

[Hyper-IL6; hyper-interleukin-6] Fischer et al (1997) have described the construction of a stable and highly bioactive designer cytokine (see also: Muteins) consisting of a fusion protein between IL6 and a soluble IL6 receptor. This hybrid, designated H-IL6 (Hyper-IL6), has been used for the expansion of human hematopoietic progenitor cells (see also: hematopoiesis, hematopoietic stem cells) and is useful in cases in which cells do not respond to IL6 but require a stable complex consisting of IL6 and a soluble IL6 receptor. H-IL6 is fully active on ... ... ... ...
 
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Entry last modified: January 2021