MIH |
MIHB |
Inab |
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[mammalian IAP homolog A] The cDNA for this protein has been isolated by Uren et al (1996) together with those encoding MIHA and MIHC. MIHC shares 73 % identity with MIHB and 43 % identity with MIHA.
MIHA inhibits apoptosis caused by overexpression of ICE and apoptosis induced by serum withdrawal. The protein binds to TRAF1 and TRAF2 and also interacts with the apoptosis-inhibitory protein SMAC. The protein has been renamed BIRC4 [baculoviral IAP repeat-containing protein-4]. See: IAP [inhibitor of apoptosis].
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