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MIHB

[mammalian IAP homolog B] The cDNA for this protein has been isolated by Uren et al (1996) together with those encoding MIHA and MIHC. MIHC shares 73 % identity with MIHB and 43 % identity with MIHA. The protein binds to TRAF1 and TRAF2 and also interacts with the apoptosis-inhibitory protein SMAC. MIHB inhibits apoptosis caused by overexpression of ICE and apoptosis induced by serum withdrawal.

The protein has been renamed BIRC2 [baculoviral IAP repeat-containing protein-2]. See: IAP [ ... ... ... ... ... Subscribe to continue reading! ... ...

 

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