s-gicerin |
SgII |
ELFADKVPKTAENFRAL |
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[Autocrine Schwann cell growth-inhibitory factor] This protein of 35 kDa protein has been isolated from rat Schwann cells. This growth-inhibitory factor is produced by the Schwann cells and acts in an autocrine or paracrine manner. The factor induces self induced growth suppression and counteracts the mitogenic action of PDGF and axon-associated stimuli in serum-free conditions.
The factor has the N-terminal sequence and approximate molecular mass of the C-propeptide of rat alpha-1-procollagen I.
For other proteins (or fragments thereof) with at least one additional activity that differs from the established 'classical' activity of the parent protein see also:
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