T2

A transcriptionally active open reading frame found within the terminal inverted repeats of Shope fibroma virus (Smith et al, 1991). It encodes a protein related to the cellular TNF receptor. T2 is secreted by virus-infected cells. It specifically binds both TNF-alpha and TNF-beta and inhibits binding of these cytokines to native TNF receptors on cells.

The terminal regions of two other Leporipoxviruses (myxomavirus and malignant rabbit fibroma virus) also encode a closely related T2 homolog with all the features of a structural motif predicted for a secreted TNF binding protein ... ... ... ...
 
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Entry last modified: January 2002