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[THAP domain containing, apoptosis associated protein 1; Thanatos-associated protein 1] Roussigne et al (2003) have reported that THAP1 is a nuclear pro-apoptotic factor associated with promyelocytic leukemia nuclear bodies, which are discrete subnuclear domains organized by the promyelocytic leukemia protein PML. THAP1 is one member of a large family of proteins containing a THAP domain.
THAP1 potentiates cell death by apoptosis induced either by serum withdrawal or TNF-alpha. THAP1 interacts with par-4 [prostate apoptosis response protein 4]. Endogenous par-4
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