TSGH9201

This cell line has been established from a human signet ring gastric carcinoma. The cells secrete tumor markers CEA and CA 125. They are not tumorigenic in athymic nude mice. The cells express TGF-alpha and high levels of EGF receptor. Cell growth is inhibited upon EGF withdrawal.

The cells express the retinoic acid receptor beta and gamma. Cell growth is inhibited by all-trans-retinoic acid, leading to an arrest in the G0/G1 phase of the cell cycle.

Cell growth is suppressed also by IFN-alpha and IFN-gamma, causing cell cycle arrest. IFN-gamma also increases ... ... ... ...
 
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Entry last modified: January 2002