TWEAK

[TNF-like weak inducer of apoptosis] TWEAK is a member of the TNF family of proteins. TWEAK has the same sequence as APO-3 ligand (see: APO-3). Based on homology with other members of the TNF ligand protein superfamily the ligand is referred to also as TNF ligand superfamily member 12 [TNFSF12]. Another designation is DR3LG [DR3 ligand], which refers to the fact that this protein is a ligand for DR3 [death receptor-3]. For a hybrid protein derived from TWEAK and APRIL see: TWE-PRIL.

Transcripts are found in many different tissues. The protein is secreted efficiently from cells. TWEAK induces ... ... ... ...
 
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Entry last modified: July 2004