TXNRD1 |
TY5 |
CRP-V |
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[transcript Y] TY is related very closely to IL1-beta Convertase (51 % amino acid identity) and another protein, transcript X (see: TX) (75 % amino acid identity). TY has protease activity on its own precursor but fails to process the IL1-beta precursor. Like IL1-beta Convertase and TX, TY is able to induce cell death by apoptosis when overexpressed in COS cells. TY therefore represents a new member of the growing family of apoptosis inducing ICE-related cysteine proteases (Faucheu et al, 1996).
TY is identical with ICErel-3. It has been suggested that TY be renamed
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