Unc-53 homolog 3 |
UNC93 |
Unique cartilage matrix-associated protein b |
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[uncoordinated locomotion-71] The Caenorhabditis elegans gene UNC71 encodes a member of the ADAM protein family of matrix metalloproteinases, which possesses an inactive metalloprotease domain. Many UNC71 mutations affect the disintegrin and the cysteine-rich domains of the protein, suggesting that the protein may play a major role in cell adhesion.
UNC71 appears to be expressed in a selected set of cells. Knock-out worms lacking expression of UNC71 display distinct defects in motor axon guidance and sex myoblast migration. The analysis of double-mutants shows that UNC71 probably functions in a combinatorial manner with integrins and UNC6
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