cIAP2

[cellular inhibitor of apoptosis-1] The gene for this protein has been cloned by Rothe et al (1995). The protein was identified as a TNF receptor-associated factor. It does not interact directly with the TNF receptor but associates with TRAF1 and TRAF2.

The protein has been renamed BIRC3 [baculoviral IAP repeat-containing protein-3]. See: IAP. See also: Apoptosis.

cIAP2 can directly bind to activated caspase-3 and caspase-7 and inhibit their activities (Deveraux et al, 1997; Roy et al, 1997). Mutational analysis shows that the copies of a BIR domain ... ... ... ...
 
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Entry last modified: January 2012