karyolysis

this term refers to the dissolution of cell nuclei in dying cells. In Hematoxylin and Eosin stains a very early sign of karyolysis may be a lessening of nuclear basophilia, i.e. less staining with hematoxylin. Karyolysis is usually preceeded by pyknosis, a shrinking of the nucleus that is associated with an increase of nuclear basophilia (for overview see also: Majno et al, 1995; Trump et al, 1997).

Takada S et al (2020) have reported that DNASE1L3 causes karyolysis in necrotic hepatocytes.

The term karyolytic bodies found in some older publications usually refers to nuclei in various stages of degeneration that have been observed in various cell types in various organisms (see Bronson RT, 1981 and ... ... ... ...
 
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Entry last modified: March 2023