CCL-185

A human non-small cell lung carcinoma line that does not require cytokines for growth and maintenance. The cell line has been used to quantify the antiproliferative activity of human IL4 present in plasma and serum samples (Page et al, 1996, Topp et al, 1993) (see also: bioassays).

The assay is 100-fold less sensitive to IFN-alpha, TNF-alpha, IL1-beta, and IL13 and can be made specific for IL4 by inclusion of specific neutralizing antibodies for IL4. The cells do not respond to IL2, IL3, IL5, IL6, ... ... ... ...
 
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Entry last modified: February 2001