|COPE Homepage||Bottom of page||Previous entry:
chemokine (C-X-C motif) ligand 16
please show your appreciation
by donating what you can afford.
[Glioma-derived growth factor] One specific factor, designated GDGF-1, is a homodimer of a protein structurally closely related to the A-chain of PDGF. This PDGF-related factor also binds to the same receptors as PDGF-A.
In contrast to PDGF GDGF-1 shows a reduced mitogenic activity. It only stimulates weakly the autophosphorylation of its receptor and does not possess chemotactic activities (see also: Chemotaxis). GDGF-1 modulates the expression of the receptor for EGF (see also: Receptor transmodulation).
The factor known as GDGF-2 is very likely to the heterodimeric PDGF consisting of the A and the B-chain.
Another factor of > 200 kDa, described also as GDGF-2, is produced by several human malignant glioma cell lines stimulated by bacterial lipopolysaccharides. The malignant glioma cell line D-54 MG constitutively produces this type of GDGF-2. This factor shows growth activity for BALB 3T3 cells (clone A31). The activity is not neutralized by antibodies to TGF-alpha, TGF-beta, PDGF, VEGF or TNF-alpha.
Copyright © 2012 by H IBELGAUFTS. All rights reserved.
ENTRY LAST MODIFIED: January 2002
See REFERENCES for entry GDGF.
Click BACKLINKS to see which COPE entries contain the term GDGF .
|COPE Homepage||Top of Page|
|SUPPORT COPE | Santa Claus | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials|
|COPE is looking for long-term support from a company appreciating and committed to communication biology|
| Access to COPE is free only for academic institutions and non-profit organizations. |
OTHER USERS: must contact COPE and pay a site licence fee.