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[Glioma-derived growth factor] One specific factor, designated GDGF-1, is a homodimer of a protein structurally closely related to the A-chain of PDGF. This PDGF-related factor also binds to the same receptors as PDGF-A.

In contrast to PDGF GDGF-1 shows a reduced mitogenic activity. It only stimulates weakly the autophosphorylation of its receptor and does not possess chemotactic activities (see also: Chemotaxis). GDGF-1 modulates the expression of the receptor for EGF (see also: Receptor transmodulation).

The factor known as GDGF-2 is very likely to the heterodimeric PDGF consisting of the A and the B-chain.

Another factor of > 200 kDa, described also as GDGF-2, is produced by several human malignant glioma cell lines stimulated by bacterial lipopolysaccharides. The malignant glioma cell line D-54 MG constitutively produces this type of GDGF-2. This factor shows growth activity for BALB 3T3 cells (clone A31). The activity is not neutralized by antibodies to TGF-alpha, TGF-beta, PDGF, VEGF or TNF-alpha.

Copyright 2012 by H IBELGAUFTS. All rights reserved.


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