COPE Advertising options


http://immunospot.com/index.php?id=233 Cell Sciences Inc http://www.promokine.info/products/cytokines-growth-factors/cytokines-growth-factors-soluble-receptors/animal-free-endotoxin-free-cytokines-growth-factors/

COPE Homepage Bottom of page Previous entry:
GDF16
Next entry:
GDGF-1
Random entry:
spIL33
Search COPE:

Please donate

If you find COPE helpful,
please show your appreciation
by donating what you can afford.

GDGF

[Glioma-derived growth factor] One specific factor, designated GDGF-1, is a homodimer of a protein structurally closely related to the A-chain of PDGF. This PDGF-related factor also binds to the same receptors as PDGF-A.

In contrast to PDGF GDGF-1 shows a reduced mitogenic activity. It only stimulates weakly the autophosphorylation of its receptor and does not possess chemotactic activities (see also: Chemotaxis). GDGF-1 modulates the expression of the receptor for EGF (see also: Receptor transmodulation).

The factor known as GDGF-2 is very likely to the heterodimeric PDGF consisting of the A and the B-chain.

Another factor of > 200 kDa, described also as GDGF-2, is produced by several human malignant glioma cell lines stimulated by bacterial lipopolysaccharides. The malignant glioma cell line D-54 MG constitutively produces this type of GDGF-2. This factor shows growth activity for BALB 3T3 cells (clone A31). The activity is not neutralized by antibodies to TGF-alpha, TGF-beta, PDGF, VEGF or TNF-alpha.


Copyright 2012 by H IBELGAUFTS. All rights reserved.
ENTRY LAST MODIFIED: January 2002



 

See REFERENCES for entry GDGF.

Click BACKLINKS to see which COPE entries contain the term GDGF .




COPE Homepage Top of Page


 
 
SUPPORT COPE | Santa Claus | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Please inquire. COPE is looking for long-term support from a company appreciating and committed to communication biology

              Created, developed, and maintained by Prof Dr H Ibelgaufts              
About the author of COPE
  |    Contact COPE   |    postcard and stampware   |    Terms & Conditions


Access to COPE is free only for academic institutions and non-profit organizations.
OTHER USERS: must contact COPE and pay a site licence fee.

U L T R A   P O S S E   N E M O   O B L I G A T U R