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MCAF

[monocyte chemotactic and activating factor] This factor of 15 kDa (76 amino acids) is called also MCF (macrophage chemotactic factor) or TSG-8 (see: TSG genes).

MCAF is produced by monocytes and macrophages, fibroblasts, endothelial cells, keratinocytes, smooth muscle cells, astrocytes. and various tumor cells lines. The factor was detected initially during the purification of IL8. Inducers for the synthesis of MCAF are IL1, which also prolongs the biological half life of M-CSF mRNA, TNF, PDGF, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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