PM
[pregnancy mitogen] This biochemically uncharacterized factor of approximately 10 kDa is isolated from the serum of pregnant women (Kineman et al, 1991). It is present in serum samples from second trimester as well as term-pregnant women, but not in those of adult men or cycling females.
PM induces rapid proliferation of the rat lymphoma cell line Nb2. PM activity in the Nb2 cell bioassay is not affected by the presence of Prolactin antiserum. Its activity is immunoneutralized by coincubation with anti-placental lactogen serum and, to a lesser extent, by anti-growth hormone serum (see also:
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