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SKALP

[Skin-derived antileukoproteinase] This name has been given to activities identified originally as EIA [Elastase inhibiting activity] in the epidermis from lesions and in psoriatic scales (Schalkwijk et al, 1990; Schalkwijk et al, 1991). These authors have shown that SKALP leukocyte elastase inhibitors are expressed also in human keratinocytes. SKALP has been found also in the urine of psoriatic patients and healthy controls (Alkemade et al, 1992).

The protease activity has been shown subsequently to be identical with elafin.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: ... ... ... ... ... Subscribe to continue reading! ... ...

 

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