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Systemic inflammatory response syndrome

This syndrome is generally seen as a systemic expression of multiple inflammatory mediators (cytokines and cytokine signals that normally function in an autocrine, paracrine, or juxtacrine fashion together with oxygen free radicals, coagulation factors). Not only pro-inflammatory cytokines but also anti-inflammatory cytokines are elevated in the blood stream and the condition has been referred to as a "Cytokine storm" (for overview see: Shimabukuro-Vornhagen et al, 2018) or, more scientifically) cytokinemia or hypercytokinemia (see also: cytokine release syndrome).

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