THANK

[TNF homolog activating apoptosis nuclear factor-kappaB c-Jun NH2-terminal kinase] THANK is a type 2 transmembrane protein that belongs to the TNF family or proteins (Mukhopadhyay et al, 1999). In the nomenclature of CD antigens this protein has been given the designation CD257. Another designation is TNFSF13B [TNF ligand superfamily member 13B].

THANK mRNA is expressed at high levels by peripheral blood leukocytes, lymph node, spleen, thymus, and also by a variety of hematopoietic cell lines. Treatment of human myeloid U937 cells with purified THANK activates nuclear transcription factor NF-kappa-B ... ... ... ...
 
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Entry last modified: January 2004