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THS119

This primitive hematopoietic cell line has been established from the bone marrow of temperature-sensitive SV40 T-antigen transgenic mice (Yanai et al, 1999).

The cells express Kit, Sca-1 and CD34(low). They do not express hematopoietic lineage surface markers of differentiated hematopoietic cells, their phenotype being Gr-1(-), TER-119(-), Mac-1(-), CD3(-), B220(-).

Maintenance of these cells depends on the presence of the stromal cell line TBR59. THS119 cells form cobblestone areas underneath the layer of ... ... ... ... ... Subscribe to continue reading! ... ...

 

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