Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala |
THSCa |
Amoebapore C |
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This primitive hematopoietic cell line has been established from the bone marrow of temperature-sensitive SV40 T-antigen transgenic mice (Yanai et al, 1999).
The cells express Kit, Sca-1 and CD34(low). They do not express hematopoietic lineage surface markers of differentiated hematopoietic cells, their phenotype being Gr-1(-), TER-119(-), Mac-1(-), CD3(-), B220(-).
Maintenance of these cells depends on the presence of the stromal cell line TBR59. THS119 cells form cobblestone areas underneath the layer of
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