Cytomegalovirus pp65 |
cytomegalovirus r131 protein |
SFTP4 |
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This protein is encoded in the genome of rat cytomegalovirus by gene r129 (Vomaske et al, 2012). r129 is expressed in vivo during viral persistence and encodes a functional CC-Chemokine that is released from infected cells. Recombinant r129 is chemotactic for primary rat lymphocytes and specifically recruits naïve and/or central memory CD4(+) T-cells. r129 binds to chemokine receptors CCR3, CCR4, CCR5, and CCR7. The protein has been implicated in accelerating transplant vascular sclerosis in a rat heart transplant model.
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