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[Cytokine 14, human] HC14 cDNA has been cloned by Chang et al (1989). Its expression in macrophages is inducible by IFN-gamma. HC14 belongs to the family of chemotactic cytokines known as Chemokines (subgroup of CC-Chemokines). The factor is known also as SCYA8. The approved gene symbol is CCL8. The factor is identical with MCP-2.
This factor is known mainly because of its chemotactic activity. For an unrelated function as an antimicrobial peptide in innate immunity see: CCL8. For other proteins/peptides with functions in innate immunity
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