MRGX2 |
MRIT-alpha-2 |
Death associated protein 3 |
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[Mach-Related Inducer of Toxicity] MRIT possesses overall sequence homology to FLICE (MACH; caspase-8) but is devoid of caspase activity. MRIT interacts with caspase-8 and FADD and BCLxL and is thus involved in the regulation of cell death by apoptosis (Han et al, 1997).
An isoform of MRIT, MRIT-alpha-2, that contains only one death effector domain (DED), has been cloned by Han et al (1997).
MRIT is known also as Casper, CASH, CFLAR, CLARP, FLAME-1,
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