TPO

[thrombopoietin] A general term, known also as TSF (thrombopoiesis stimulating factor) for mediator substances that function as natural stimulators of megakaryocytopoiesis and, thus, promote the differentiation of platelets (see also: hematopoiesis). The approved gene symbol is THPO.

TPO stimulates an increase in the sizes and numbers of megakaryocytes, DNA content, endomitosis, and maturation. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. TSF has been described to be identical with ... ... ... ...
 
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Entry last modified: March 2000