fos

c-fos is the cellular homolog of the viral v-fos oncogene found in FBJ (Finkel-Biskis-Jinkins) and FBR murine osteosarcoma viruses (MSV) (hence: FBJ murine osteosarcoma viral oncogene homolog).

The human fos gene maps to chromosome 14q21-q31. fos has been identified as TIS28, a gene inducible in several cell types by Phorbol esters (see also: TIS genes).

c-fos is thought to have an important role in signal transduction, cell proliferation, and differentiation. It is a nuclear protein which, in combination with other transcription factors (see, for example: ... ... ... ...
 
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Entry last modified: November 2001